Cellular senescence is a natural part of the aging
process in which cells no longer function optimally. Senescent cells can
accumulate over time, affecting the day-to-day function of the healthy
cells around them. Senolytic compounds selectively target senescent
cells.
Senolytic Activator Benefits
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Helps the body manage senescent cells
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Promotes youthful, healthy cellular function
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Supports systemic rejuvenation
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Made with black tea theaflavins, apigenin, plus highly
absorbable quercetin and fisetin
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Convenient once-a-week dosing
Ultra-absorbable Quercetin and Fisetin
These two plant flavonoids have many health benefits,
but traditional forms are hard to absorb. So we use quercetin and
fisetin that are encased in a phytosome sphere, aiding in their
absorption and making them much, much more bioavailable. The plant-based
flavonoid apigenin is included since it complements the senolytic
activity of quercetin and black tea compounds.
Product Details
Cellular senescence is a natural part of the aging
process in which cells no longer function optimally. Senescent cells can
accumulate over time, affecting the day-to-day function of the healthy
cells around them.
Senolytic compounds selectively target senescent
cells. New research indicates that black tea theaflavins and quercetin
target specific biological pathways, making it easier for the body to
manage senescent cells.
Theaflavins reduce senescent cell burden
Theaflavins are compounds derived from Camellia
sinensis (tea plant). These compounds have widespread health benefits,
supporting healthy cell division and healthy inflammatory response.
New research indicates that theaflavins may be
especially helpful for reducing senescent cell burden. In pre-clinical
models, theaflavins helped powerfully inhibit the accumulation of
particular cell senescence biomarkers.
Quercetin promotes cellular health and more
Quercetin supports endothelial and cardiovascular
health, promotes healthy immune function and more. The value of
quercetin has been recognized for some time. But its potential to
meaningfully impact whole body rejuvenation is just starting to be
uncovered through its senolytic activity. The discovery that quercetin
is a senolytic compound has drawn significant attention to this
innovative approach to combat aging.
Better absorption than standard types of
quercetin
Standard quercetin is hard to absorb. But this
formulation features our new quercetin phytosome, a phospholipid sphere
that encases the quercetin, aiding in its absorption and making it up to
50 times more bioavailable.
Easy-to-absorb fisetin to boost longevity at
the cellular level
Fisetin is terrific for whole-body health. It’s a
powerful senolytic compound, meaning it actively target senescent cells,
the ones that no longer function optimally. Fisetin helps encourage the
body’s natural pathways for clearing senescent cells, which allows
healthy cells to flourish.
Another important aspect of cellular longevity is
sirtuin function. Sirtuin proteins keep your cells performing at their
best—but sirtuin activity declines with age. Fisetin has been shown in
preclinical studies to encourage youthful, healthy sirtuin function.
But during digestion, much of fisetin is rapidly
converted into other compounds by a process called conjugation. That’s
why we protected fisetin by combining it with galactomannans, a type of
fiber derived from fenugreek seed. Doing so makes it up to 25 times more
readily available than standard fisetin. That means it circulates in
your system longer and your body has more time to access fisetin’s many
health benefits.
Apigenin
Life Extension has identified apigenin, a natural
flavonoid, as a powerful addition to our Senolytic Activator® formula.
Quercetin and theaflavins from black tea target senescent cells, but not
all of them.
The remaining senescent cells create compounds known
collectively as Senescence Associated Secretory Phenotype, or SASP.
Apigenin helps inhibit remaining senescent cells from making SASP to
support cellular and tissue health—a critical aspect of healthy aging.
Convenient, once-weekly formula
For those who aren’t keen on adding another
supplement to their regimen, here’s good news: Senolytic research
indicates that intermittent dosing in pre-clinical studies is effective
at supporting healthspan.4 So, Senolytic Activator® instructions call
for taking just three vegetarian capsules, once a week. Manage senescent
cells, promote healthy cellular function and support overall longevity
with Senolytic Activator®.