What is Forskolin?

Forskolin

(3R,​4aR,​5S,​6S,​6aS,​10S,​10aR,​10bS)-​6,​10,​10b-​trihydroxy-​3,​4a,​7,​7,​10a-​pentamethyl-​1-​oxo-​3-​vinyldodecahydro-​1H-​benzo[f]​chromen-​5-​yl acetate

Forskolin is a compound that is produced by the plant Coleus forskohlii. Coleus forskohlii is part of an extensive genus of mints native to the tropical and subtropic regions of India, and the eastern region of Africa. Forskolin possesses unique biological activity. The basic mechanism of action of forskolin is the activation of an enzyme, adenylate cyclase, which resensitizes cell receptors and increases cyclic adenosine monophosphate (cAMP) in cells. Cyclic AMP is perhaps the most important cell-regulating compound. Once formed it activates many other enzymes involved in diverse cellular functions. Cyclic AMP is necessary for the proper biological response of cells to hormones and other extracellular signals. It is required for cell communication in the hypothalamus/pituitary gland axis and for the feedback control of hormones.

There have been many uses of forskolin in the field of Ayurvedic medicine since the ancient times. It has been utilized in the treatment of heart diseases, such as angina or chest pain, and hypertension or high blood pressure. Some health providers also give this herbal medicine intravenously, for the treatment of heart failure.

In the treatment of respiratory disorders like asthma, its powdered form has been used for inhalation.

Some patients with skin problems such as psoriasis and eczema have also been given forskolin orally. Psoriasis is a chronic skin problem characterized by red, thick, and dry patches of skin. Eczema is a type of dermatitis or skin inflammation.

Other conditions that are said to benefit from the oral intake of forskolin include bladder infections, obesity, menstrual pains, urinary tract infections, and insomnia.

For eye problems like glaucoma, forskolin has also been administered as an eyedrop.

How To Obtain Forskolin Forskolin comes in capsules containing 10 mg. of elemental forskolin extracted from the Coleus forshohlii herb. One capsule a day is suggested for the first two weeks. One additional capsule can be added every two weeks. Up to six capsules a day can be used. Click on the image to the left for additional information about Life Extension brand forskolin.